Nikon D500 has a
21.0MP APS-C (23.5 x 15.7 mm ) sized CMOS sensor and features Expeed 5 processor. On the other hand, Fujifilm X-T200 has a
24.0MP APS-C (23.5 x 15.7 mm ) sized CMOS sensor .
Another difference between these two cameras is that Nikon D500's sensor lacks anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the D500 and X-T200 sensor size comparison.
Sensor Size and Resolution Comparison image of Nikon D500 and Fujifilm X-T200 Cameras
Nikon D500 and Fujifilm X-T200 have the same sensor sizes so they will provide same level of control over the depth of field when used with same focal length and aperture. On the other hand, since Nikon D500 has 16% larger pixel area compared to Fujifilm X-T200, it has potential to collect more light on pixel level hence have less noise in low light / High ISO images.
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Nikon D500
or the
Fujifilm X-T200 ,
including hyperfocal distance.