Leica M-E Typ 220 has a
18.0MP Full frame (36 x 24 mm ) sized CCD sensor . On the other hand, Nikon Z50 has a
21.0MP APS-C (23.5 x 15.7 mm ) sized BSI-CMOS sensor and features Expeed 6 processor.
One other difference between these two cameras that is worth mentioning is that Nikon Z50's sensor doesn't have an anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the M-E Typ 220 and Z50 sensor size comparison.
Sensor Size and Resolution Comparison image of Leica M-E Typ 220 and Nikon Z50 Cameras
As seen above, Leica M-E Typ 220 has a 2.3x Larger sensor area than Nikon Z50. Larger sensors give photographer more control on the depth of field and blurry background compared to smaller sensor when shot in same focal length and aperture.
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Leica M-E Typ 220
or the
Nikon Z50 ,
including hyperfocal distance.
One thing to watch when comparing these two: they have different sensor sizes
(Full frame versus APS-C),
so compare them at the same framing rather than the same focal length.
Put the same focal length on the smaller sensor and it will show less depth of
field, not more, because it also crops tighter. The calculator shows the
full frame equivalent focal length for each body so you can match the framing.