Here we are comparing two cameras with different body types: Fujifilm GFX 50S, which was introduced in January 2017 is a Pro Mirrorless camera with a 51.0MP Medium format sensor whereas Pentax 645Z, which was introduced in April 2014 is a Pro DSLR camera with a 51.0MP Medium format sensor.
Despite some fundamental differences of these two body types, Mirrorless cameras are becoming serious alternatives to DSLR cameras thanks to their size/weight advantages and recent improvements in their focus speeds , which makes this comparison even more interesting. Fortunately, you can't go wrong with any of these cameras as we rank them amongst Top 10 cameras in their classes. Fujifilm GFX 50S is ranked #2
out of 39 Pro Mirrorless cameras with an overall score of 99 whereas Pentax 645Z is ranked #1
out of 34 Pro DSLR cameras with an overall score of 85.
Let's have a brief look at the main features of Fujifilm GFX 50S and Pentax 645Z before getting into our more detailed comparison.