Both Samsung NX100 and Canon 50D have APS-C sized 15.0 MP resolution sensors so sensor size and resolution is not a differentiator between these two cameras.
Below you can see the NX100 and 50D sensor size comparison.
Sensor Size and Resolution Comparison image of Samsung NX100 and Canon 50D Cameras
Samsung NX100 and Canon 50D have almost the same sensor size, so neither of them has any significant advantage over the other in terms of providing control over depth of field when used with the same focal length and aperture.
DxOMark Sensor Scores
DxOMark is a benchmark that scientifically assesses image quality of camera sensors. It scores camera sensors for color depth (DXO Portrait), dynamic range (DXO Landscape) and low-light sensitivity (DXO Sports), and also gives them an overall score. Samsung NX100 and Canon 50D sensors have been tested by DxO and the results show that 50D has a better overall score of 63, 1 points higher compared to NX100's score of 62.
Model
Overall
Color Depth
Dynamic Range
Low-light ISO
Samsung NX100
62
22.6 bits
10.7 Evs
563 ISO
Canon 50D
63
21.8 bits
11.4 Evs
696 ISO
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Samsung NX100
or the
Canon 50D ,
including hyperfocal distance.