Here we are comparing two cameras with different body types: Pentax 645Z, which was introduced in April 2014 is a Pro DSLR camera with a 51.0MP Medium format sensor whereas Fujifilm GFX 50R, which was introduced in September 2018 is a Pro Mirrorless camera with a 51.0MP Medium format sensor.
Despite some fundamental differences of these two body types, Mirrorless cameras are becoming serious alternatives to DSLR cameras thanks to their size/weight advantages and recent improvements in their focus speeds , which makes this comparison even more interesting. Fortunately, you can't go wrong with any of these cameras as we rank them amongst Top 10 cameras in their classes. Pentax 645Z is ranked #1
out of 34 Pro DSLR cameras with an overall score of 86 whereas Fujifilm GFX 50R is ranked #6
out of 38 Pro Mirrorless cameras with an overall score of 96.
Let's have a brief look at the main features of Pentax 645Z and Fujifilm GFX 50R before getting into our more detailed comparison.