Panasonic S5 II has a
24.0MP Full frame (35.6 x 23.8 mm ) sized CMOS sensor and features Venus Engine processor. On the other hand, Canon 6D MII has a
26.0MP Full frame (35.9 x 24 mm ) sized CMOS sensor and features DIGIC 7 processor.
Another difference between these two cameras is that Panasonic S5 II's sensor lacks anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the S5 Mark II and 6D MII sensor size comparison.
Sensor Size and Resolution Comparison image of Panasonic S5 II and Canon 6D MII Cameras
Panasonic S5 II and Canon 6D MII have almost the same sensor size, so neither of them has any significant advantage over the other in terms of providing control over depth of field when used with the same focal length and aperture.
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Panasonic S5 II
or the
Canon 6D MII ,
including hyperfocal distance.