Panasonic S1R II has a
44.3MP Full frame (36 x 24 mm ) sized CMOS sensor and features Venus Engine processor. On the other hand, Canon 5D MII has a
21.0MP Full frame (36 x 24 mm ) sized CMOS sensor and features Digic 4 processor.
Panasonic S1R II's sensor provides 23.3MP more than Canon 5D MII's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Another difference between these two cameras is that Panasonic S1R II's sensor lacks anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the S1R II and 5D MII sensor size comparison.
Sensor Size and Resolution Comparison image of Panasonic S1R II and Canon 5D MII Cameras
Panasonic S1R II and Canon 5D MII have the same sensor sizes so they will provide same level of control over the depth of field when used with same focal length and aperture. On the other hand, since Canon 5D MII has 109% larger pixel area (41.08µm 2 vs 19.60µm 2 ) compared to Panasonic S1R II, it has larger pixel area to collect light hence potential to have less noise in low light / High ISO images.
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Panasonic S1R II
or the
Canon 5D MII ,
including hyperfocal distance.