Both Panasonic S1 and Canon R6 II have Full frame sized 24.0 MP resolution sensors so sensor size and resolution is not a differentiator between these two cameras.
Another difference between these two cameras is that Panasonic S1's sensor lacks anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the S1 and R6 II sensor size comparison.
Sensor Size and Resolution Comparison image of Panasonic S1 and Canon R6 II Cameras
Panasonic S1 and Canon R6 II have almost the same sensor size, so neither of them has any significant advantage over the other in terms of providing control over depth of field when used with the same focal length and aperture.
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Panasonic S1
or the
Canon R6 II ,
including hyperfocal distance.
