Nikon D500 has a
21.0MP APS-C (23.5 x 15.7 mm ) sized CMOS sensor and features Expeed 5 processor. On the other hand, Samsung Galaxy NX has a
20.0MP APS-C (23.5 x 15.7 mm ) sized CMOS sensor and features DRIMe IV processor.
Another difference between these two cameras is that Nikon D500's sensor lacks anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the D500 and Galaxy NX sensor size comparison.
Nikon D500 and Samsung Galaxy NX have the same sensor sizes so they will provide same level of control over the depth of field when used with same focal length and aperture.