Canon M5 has a
24.0MP APS-C (22.3 x 14.9 mm ) sized CMOS sensor and features Digic 7 processor. On the other hand, Fujifilm X-H2S has a
26.0MP APS-C (23.5 x 15.6 mm ) sized Stacked BSI X-Trans sensor and features X-Processor 5 processor.
One other difference between these two cameras that is worth mentioning is that Fujifilm X-H2S's sensor doesn't have an anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the M5 and X-H2S sensor size comparison.
As seen above, Fujifilm X-H2S has a 1.1x Larger sensor area than Canon M5. Larger sensors give photographer more control on the depth of field and blurry background compared to smaller sensor when shot in same focal length and aperture.