Both Canon 5DS and Canon 5DS R have Full frame sized 51.0 MP resolution sensors so sensor size and resolution is not a differentiator between these two cameras.
One other difference between these two cameras that is worth mentioning is that Canon 5DS R's sensor doesn't have an anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the 5DS and 5DS R sensor size comparison.
Sensor Size and Resolution Comparison image of Canon 5DS and Canon 5DS R Cameras
Canon 5DS and Canon 5DS R have the same sensor sizes so they will provide same level of control over the depth of field when used with same focal length and aperture.
DxOMark Sensor Scores
Both Canon 5DS and Canon 5DS R sensors have been tested by DxoMark. DxoMark scores camera sensors for color depth (DXO Portrait), dynamic range (DXO Landscape) and low-light sensitivity (DXO Sports), and also gives them an overall score. Of the two cameras that we are comparing, 5DS has scored 87, 1 points higher than 5DS R.
Model
Overall
Color Depth
Dynamic Range
Low-light ISO
Canon 5DS
87
24.7 bits
12.4 Evs
2381 ISO
Canon 5DS R
86
24.6 bits
12.4 Evs
2308 ISO
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Canon 5DS
or the
Canon 5DS R ,
including hyperfocal distance.