Canon 5DS R has a 51.0MP Full frame (36 x 24 mm ) sized CMOS sensor and features Dual DIGIC 6 processor. On the other hand, Nikon D780 has a 25.0MP Full frame (35.9 x 23.9 mm ) sized BSI-CMOS sensor and features Expeed 6 processor.
Canon 5DS R's sensor provides 26MP more than Nikon D780's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Another difference between these two cameras is that Canon 5DS R's sensor lacks anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moire occurring in certain scenes.
Below you can see the 5DS R and D780 sensor size comparison.
Canon 5DS R and Nikon D780 have almost the same sensor size so none of them has any significant advantage over other in providing control over depth of field when used with same focal length and aperture.