Panasonic FZ300 has a 12.0MP 1/2.3" (6.17 x 4.55 mm ) sized CMOS sensor and features Venus Engine processor. On the other hand, Panasonic FZ80 has a 18.0MP 1/2.3" (6.17 x 4.55 mm ) sized BSI-CMOS sensor and features Venus Engine processor.
Panasonic FZ80's sensor provides 6MP more than Panasonic FZ300's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Below you can see the FZ300 and FZ80 sensor size comparison.
Panasonic FZ300 and Panasonic FZ80 have sensor sizes so they will provide same level of control over the depth of field when used with same focal length and aperture. On the other hand, since Panasonic FZ300 has 49% larger pixel area compared to Panasonic FZ80, it has potential to collect more light on pixel level hence have less noise in low light / High ISO images.