Nikon D80 has a 10.0MP APS-C (23.6 x 15.8 mm ) sized CCD sensor . On the other hand, Sigma DP2x has a 5.0MP APS-C (20.7 x 13.8 mm ) sized CMOS (Foveon X3) sensor and features True II processor.
Nikon D80's sensor provides 5MP more than Sigma DP2x's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Below you can see the D80 and DP2x sensor size comparison.
As seen above, Nikon D80 has a 1.3x Larger sensor area than Sigma DP2x. Larger sensors give photographer more control on the depth of field and blurry background compared to smaller sensor when shot in same focal length and aperture.