Leica S2 has a
38.0MP Medium format (45 x 30 mm ) sized CCD sensor . On the other hand, Fujifilm GFX 50S II has a
51.0MP Medium format (44 x 33 mm ) sized CMOS sensor and features X-Processor 4 processor.
Fujifilm GFX 50S II's sensor provides 13MP more than Leica S2's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Below you can see the S2 and GFX 50S II sensor size comparison.
Sensor Size and Resolution Comparison image of Leica S2 and Fujifilm GFX 50S II Cameras
Leica S2 and Fujifilm GFX 50S II have almost the same sensor size, so neither of them has any significant advantage over the other in terms of providing control over depth of field when used with the same focal length and aperture.
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Leica S2
or the
Fujifilm GFX 50S II ,
including hyperfocal distance.
