Fujifilm X100F has a 24.0MP APS-C (23.6 x 15.6 mm ) sized CMOS X-TRANS III sensor and features X-Processor Pro processor. On the other hand, Leica X Vario has a 16.0MP APS-C (23.6 x 15.8 mm ) sized CMOS sensor . Fujifilm X100F's sensor provides 8MP more than Leica X Vario's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Another difference between these two cameras is that Fujifilm X100F's sensor lacks anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moire occurring in certain scenes.
Below you can see the X100F and X Vario sensor size comparison.
Fujifilm X100F and Leica X Vario have almost the same sensor size so none of them has any significant advantage over other in providing control over depth of field when used with same focal length and aperture.