Fujifilm GFX 50S II has a
51.0MP Medium format (44 x 33 mm ) sized CMOS sensor and features X-Processor 4 processor. On the other hand, Panasonic S1R has a
47.0MP Full frame (36 x 24 mm ) sized CMOS sensor and features Venus Engine processor.
One other difference between these two cameras that is worth mentioning is that Panasonic S1R's sensor doesn't have an anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the GFX 50S II and S1R sensor size comparison.
Sensor Size and Resolution Comparison image of Fujifilm GFX 50S II and Panasonic S1R Cameras
As seen above, Fujifilm GFX 50S II has a 1.7x Larger sensor area than Panasonic S1R. Larger sensors give photographer more control on the depth of field and blurry background compared to smaller sensor when shot in same focal length and aperture.
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Fujifilm GFX 50S II
or the
Panasonic S1R ,
including hyperfocal distance.
One thing to watch when comparing these two: they have different sensor sizes
(Medium format versus Full frame),
so compare them at the same framing rather than the same focal length.
Put the same focal length on the smaller sensor and it will show less depth of
field, not more, because it also crops tighter. The calculator shows the
full frame equivalent focal length for each body so you can match the framing.