Fujifilm S1 Pro has a
3.0MP APS-C (23 x 15.5 mm ) sized CCD sensor . On the other hand, Nikon D300 has a
12.0MP APS-C (23.6 x 15.8 mm ) sized CMOS sensor and features Expeed processor.
Nikon D300's sensor provides 9MP more than Fujifilm S1 Pro's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Below you can see the S1 Pro and D300 sensor size comparison.
Sensor Size and Resolution Comparison image of Fujifilm S1 Pro and Nikon D300 Cameras
Fujifilm S1 Pro and Nikon D300 have almost the same sensor size, so neither of them has any significant advantage over the other in terms of providing control over depth of field when used with the same focal length and aperture.
Sensor size sets the circle of confusion, so it drives how much depth of field each
of these bodies gives you at a given aperture. You can calculate it exactly for the
Fujifilm S1 Pro
or the
Nikon D300 ,
including hyperfocal distance.