Sony H300 has a
20.0MP 1/2.3-inch (6.17 x 4.55 mm ) sized CCD sensor and features Bionz(R) processor. On the other hand, Fujifilm S4500 has a
14.0MP 1/2.3-inch (6.17 x 4.55 mm ) sized CCD sensor .
Sony H300's sensor provides 6MP more than Fujifilm S4500's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Below you can see the H300 and S4500 sensor size comparison.
Sony H300 and Fujifilm S4500 have the same sensor sizes so they will provide same level of control over the depth of field when used with same focal length and aperture. On the other hand, since Fujifilm S4500 has 44% larger pixel area (2.04µm2 vs 1.41µm2) compared to Sony H300, it has larger pixel area to collect light hence potential to have less noise in low light / High ISO images.