Pentax 645Z has a
51.0MP Medium format (44 x 33 mm ) sized CMOS sensor and features PRIME III processor. On the other hand, Nikon S620 has a
12.0MP 1/2.3-inch (6.08 x 4.56 mm ) sized CCD sensor .
Pentax 645Z's sensor provides 39MP more than Nikon S620's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Another difference between these two cameras is that Pentax 645Z's sensor lacks anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the 645Z and S620 sensor size comparison.
As seen above, Pentax 645Z has a 52.4x Larger sensor area than Nikon S620. Larger sensors give photographer more control on the depth of field and blurry background compared to smaller sensor when shot in same focal length and aperture.