Nikon D300 has a 12.0MP APS-C (23.6 x 15.8 mm ) sized CMOS sensor and features Expeed processor. On the other hand, Canon RP has a 26.0MP Full frame (35.9 x 24 mm ) sized CMOS sensor and features Digic 8 processor. Canon RP's sensor provides 14MP more than Nikon D300's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
Below you can see the D300 and RP sensor size comparison.
As seen above, Canon RP has a 2.3x Larger sensor area than Nikon D300. Larger sensors give photographer more control on the depth of field and blurry background compared to smaller sensor when shot in same focal length and aperture.