Leica M-Monochrom has a
18.0MP Full frame (36 x 24 mm ) sized CCD sensor . On the other hand, Panasonic GX85 has a
16.0MP Four Thirds (17.3 x 13 mm ) sized CMOS sensor and features Venus Engine processor.
One other difference between these two cameras that is worth mentioning is that Panasonic GX85's sensor doesn't have an anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moiré occurring in certain scenes.
Below you can see the M-Monochrom and GX85 sensor size comparison.
As seen above, Leica M-Monochrom has a 3.8x Larger sensor area than Panasonic GX85. Larger sensors give photographer more control on the depth of field and blurry background compared to smaller sensor when shot in same focal length and aperture.