Casio EX-Z450 has a 12.0MP 1/2.3-inch (6.17 x 4.55 mm ) sized CCD sensor . On the other hand, Nikon D810 has a 36.0MP Full frame (35.9 x 24 mm ) sized CMOS sensor and features EXPEED 4 processor.
Nikon D810's sensor provides 24MP more than Casio EX-Z450's sensor, which gives a significant advantage in real life. You can print your images larger or crop more freely.
On the other hand, please keep in mind that Max sensor resolution is not the only determinant of resolving power. Factors such as the optical elements, low pass filter, pixel size and sensor technology also affects the final resolution of the captured image.
One other difference between these two cameras that is worth mentioning is that Nikon D810's sensor doesn't have an anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moire occurring in certain scenes.
Below you can see the EX-Z450 and D810 sensor size comparison.
As seen above, Nikon D810 has a 30.7x Larger sensor area than Casio EX-Z450. Larger sensors give photographer more control on the depth of field and blurry background compared to smaller sensor when shot in same focal length and aperture.