Below you can see the front view size comparison of Canon 10D and Fujifilm S2 Pro. Canon 10D is 24mm shorter and 5mm thinner than Fujifilm S2 Pro but it is also 8mm wider.
Weight is another important factor especially when deciding on a camera that you want to carry with you all day.
Fujifilm S2 Pro is 25g lighter than the Canon 10D but we don't think this will make a significant difference.
Also keep in mind that body weight is not the only deciding factor when comparing two interchangeable camera bodies, you have to also take into account the lenses that you will be using with these bodies. Since both Canon 10D and Fujifilm S2 Pro have the same APS-C sized sensor, their lenses for a similar focal length and aperture will be similar in size and weight.