Canon 80D has a 24.0MP APS-C (22.5 x 15 mm ) sized CMOS sensor and features DIGIC 6 processor. On the other hand, Nikon D500 has a 21.0MP APS-C (23.5 x 15.7 mm ) sized CMOS sensor and features Expeed 5 processor.
Another difference between these two cameras is that Nikon D500's sensor lacks anti-alias (Low-Pass) filter. Removing anti-alias filter increases the sharpness and level of detail but at the same time, it increases the chance of moire occurring in certain scenes.
Below you can see the 80D and D500 sensor size comparison.
Canon 80D and Nikon D500 have almost the same sensor size so none of them has any significant advantage over other in providing control over depth of field when used with same focal length and aperture.